(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol
2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-
CAS: 848821-76-1
Molecular Formula: C21H15F12NO
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol - Names and Identifiers
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol - Physico-chemical Properties
| Molecular Formula | C21H15F12NO |
| Molar Mass | 525.33 |
| Density | 1.465±0.06 g/cm3(Predicted) |
| Melting Point | 113-117°C |
| Boling Point | 391.8±42.0 °C(Predicted) |
| pKa | 12.26±0.29(Predicted) |
| Storage Condition | 2-8°C |
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol - Risk and Safety
| WGK Germany | 3 |
(S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol - Introduction
2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-, also known as (2S)-2-propylpyrroline-1-carbinol, is an organic compound with the chemical formula C17H14F6NO.
Nature:
-Appearance: 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-as a white solid.
-Melting point: about 94-97 ℃.
-Solubility: Good solubility in common organic solvents.
Use:
- 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-is a chiral decarboxylation reagent commonly used in organic synthesis as a precursor to the corresponding ketone compound. It can be used to synthesize organic compounds such as chiral ketones and alcohols.
Preparation Method:
The synthesis of 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-can be carried out by the following steps:
1. The reaction of (2S)-2-propylpyrroline with benzo trifluorocarbonic anhydride in the presence of sodium carbonate to form the corresponding ester.
2. The ester reacts with hydrofluoric acid to generate the corresponding acid.
3. The acid is reacted with cyanopropanol to give 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-.
Safety Information:
There is no clear report on the safety information of 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S). However, as an organic compound, its use and handling must comply with general safety practices, such as wearing appropriate protective equipment (e. g. gloves, glasses), handling in a well-ventilated environment, and properly stored to avoid exposure to oxidants or sources of ignition. If necessary, the relevant chemical supplier or professional body should also be consulted for detailed safety information.
Nature:
-Appearance: 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-as a white solid.
-Melting point: about 94-97 ℃.
-Solubility: Good solubility in common organic solvents.
Use:
- 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-is a chiral decarboxylation reagent commonly used in organic synthesis as a precursor to the corresponding ketone compound. It can be used to synthesize organic compounds such as chiral ketones and alcohols.
Preparation Method:
The synthesis of 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-can be carried out by the following steps:
1. The reaction of (2S)-2-propylpyrroline with benzo trifluorocarbonic anhydride in the presence of sodium carbonate to form the corresponding ester.
2. The ester reacts with hydrofluoric acid to generate the corresponding acid.
3. The acid is reacted with cyanopropanol to give 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S)-.
Safety Information:
There is no clear report on the safety information of 2-Pyrrolidinemethanol, a,a-bis[3,5-bis(trifluoromethyl)phenyl]-, (2S). However, as an organic compound, its use and handling must comply with general safety practices, such as wearing appropriate protective equipment (e. g. gloves, glasses), handling in a well-ventilated environment, and properly stored to avoid exposure to oxidants or sources of ignition. If necessary, the relevant chemical supplier or professional body should also be consulted for detailed safety information.
Last Update：2024-04-10 22:29:15
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CAS: 848821-76-1
Tel: 18301782025
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QQ: 3008007409
Wechat: 18301782025
Spot supply
Product Name: (S)-α,α-Bis[3,5-bis(trifluoromethyl)phenyl]-2-pyrrolidinemethanol Request for quotationCAS: 848821-76-1
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